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Evaluation of the purified fraction of Wilbrandia (c. f. ) verticillata for antitumour activity

Rao, V. S. N; Almeida, F. R. C; Moraes, A. P; Silva, J. V; Nascimento, S. C; Moraes, M. O.

Mem. Inst. Oswaldo Cruz ; 86(supl.2): 43-45, 1991. tab

Article in English | LILACS | ID: lil-623938

ABSTRACT

Cucurbatacins are known to produce cytotoxic and anticancer activities. Two novel norcucurbitacin glucosides (Wvl and Wv2) have recently been isolated from a purified fraction obtained from the rhizome of Wilbrandia verticillata. The present study evaluates the cytotoxic and anti-tumour activities of the norcucurbitacins. We have found a regular cytotoxicity in KB cells (Cy50 = 12µg/ml) as well as a significant inhibition in the Walker 256 carcinosarcoma growth (approximately 75%).

Subject(s)

Humans , Animals , Rats , Triterpenes/isolation & purification , Triterpenes/therapeutic use , Antineoplastic Agents, Phytogenic/isolation & purification , Antineoplastic Agents, Phytogenic/therapeutic use , Brazil , Drug Screening Assays, Antitumor , KB Cells , Carcinoma 256, Walker , Phytotherapy

Correlacao morfo-eletrocardiografica dos segmentos cardiacos nos ventriculos do coracao humano. / Morpho-electrocardiographic correlation of cardiac segmentum in ventricles of human heart

Moffa, Paulo Jorge; Moraes, A. P; Pileggi, F; Jatene, A; Rodrigues, H; Didio, I. J.

Ars cvrandi cardiol ; 6(45): 36-49 passim, 1984.

Article in Portuguese | LILACS | ID: lil-24935

Subject(s)

Child, Preschool , Child , Adolescent , Adult , Middle Aged , Humans , Male , Female , Electrocardiography , Heart Ventricles

Bloqueios divisionais do ramo direito Padronizacao dos achados vetoeletrocardiograficos. / Divisional right branch block - standardization of vector electrocardiographic findings

Pastore, C. A; Moffa, Paulo Jorge; Spiritus, M. O; Tobias, N. M; Moraes, A. P; Nero Junior, Ermelindo del; Decourt, Luiz V; Pileggi, F.

Ars cvrandi cardiol ; 5(31): 11-27 passim, 1983.

Article in Portuguese | LILACS | ID: lil-14168

Subject(s)

Adolescent , Adult , Middle Aged , Humans , Bundle-Branch Block , Vectorcardiography

Bloqueio de ramos do feixe de HIS.(Curso basico de eletrocardiografia e vectocardiografia). / HIS bundle branch block (Basic course on electrocardiography and vectorcardiography)

Pastore, C. A; Moffa, Paulo Jorge; Moraes, A. P; Alfieri, Roberto Guimaräes.

RBM rev. bras. med ; 40(5): 156-61, 1983.

Article in Portuguese | LILACS | ID: lil-14388

Subject(s)

Humans , Bundle of His , Electrocardiography , Heart Block , Vectorcardiography

Bloqueios divisionais de ramo esquerdo (Curso basico de eletrocardiografia e vectocardiografia). / Divisional blocks of the left branch (Basic course on electrocardiography and vectorcardiography)

Moffa, Paulo Jorge; Moraes, A. P; Pastore, C. A.

RBM rev. bras. med ; 40(6): 194-200, 1983.

Article in Portuguese | LILACS | ID: lil-14395

Subject(s)

Humans , Electrocardiography , Heart Block , Vectorcardiography

Curso basico de eletrocardiografia e vectocardiografia. Isquemia, lesao e necrose miocardica. / Basic course of electrocardiography and vectocardiography. Ischemia, lesion and myocardial necrosis

Moraes, A. P; Moffa, P. O; Alfieri, Roberto Guimaräes.

RBM rev. bras. med ; 40(7): 252-61, 1983.

Article in Portuguese | LILACS | ID: lil-17475

Subject(s)

Humans , Cardiomyopathies , Coronary Disease , Electrocardiography , Necrosis , Vectorcardiography

A associacao metroprolol-hidroclorotiazida no tratamento da hipertensao arterial sistemica. / Association of metoprolol plus hydrochlorothiazide in the treatment of systemic arterial hypertension

Nero Júnior, Ermelindo del; Moraes, A. P; Moffa, Paulo Jorge; Pastore, C. A; Chagas, A. C.

Rev. bras. clín. ter ; 12(9): 403-7, 1983.

Article in Portuguese | LILACS | ID: lil-18336

Subject(s)

Adult , Middle Aged , Humans , Male , Female , Hydrochlorothiazide , Hypertension , Metoprolol , Drug Therapy, Combination

Ativacao cardiaca. / Cardiac activation

Moraes, A. P; Alfieri, Roberto Guimaräes; Moffa, P. O.

RBM rev. bras. med ; 39(10): 618-26, passim, 1982.

Article in Portuguese | LILACS | ID: lil-10336

Subject(s)

Electrocardiography

Eletrocardiografia e vectocardiografia. / Electrocardiography and vectorcardiography

Moraes, A. P; Alfieri, Roberto Guimaräes; Moffa, P. O.

RBM rev. bras. med ; 39(9): 556-62, 1982.

Article in Portuguese | LILACS | ID: lil-10475

Subject(s)

Electrocardiography , Heart Conduction System , Vectorcardiography

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